During PM Modi's visit to the U.S., it is expected that several areas of significance will be covered during talks with President Joe Biden. These areas include: 1. Bilateral trade and economic cooperation: Both leaders are likely to discuss ways to enhance bilateral trade and economic relations, including potential trade agreements and investment opportunities. 2. Climate change and clean energy cooperation: Given the global focus on combating climate change, discussions between the two leaders are expected to address renewable energy, sustainable development, and collaboration on climate goals. 3. COVID-19 pandemic response: The leaders may discuss strategies for addressing the ongoing COVID-19 pandemic, including vaccine distribution, research collaboration, and strengthening healthcare systems. 4. Regional security and defense partnerships: Talks may touch upon regional security challenges, defense cooperation, and joint efforts in combating terrorism, ensuring stability, and maintaining peace in the Indo-Pacific region. 5. People-to-people exchanges and education: The leaders may emphasize the importance of promoting cultural exchanges, student mobility, and educational collaborations between India and the United States. These key areas of significance are pivotal in strengthening the bilateral relationship and promoting cooperation between the two countries.