During the upcoming meeting between Indian Prime Minister Narendra Modi and U.S. President Joe Biden, several key issues are expected to be discussed. Here are the five broad areas of significance:

• COVID-19 Pandemic: Addressing the pandemic and mitigating its impact on both nations will remain at the forefront of the talks. The US has already shared several million vaccine doses with India, and discussions on vaccine production and distribution are expected to be a crucial part of the discussions.
• Economic Cooperation: Since the U.S. is India's top trading partner, the talks are expected to focus on promoting bilateral trade and investments, especially in the technology sector.
• Climate Change: Climate change and clean energy solutions will be a key area of focus during the discussions as both India and the U.S. aim to reduce emissions and work towards a sustainable future.
• Defense Cooperation: The two countries have a deepening partnership on defense issues. The talks may focus on regional security issues, terrorism, and maritime security.
• Regional Security: The situation in Afghanistan is expected to be closely monitored and discussed, with both countries sharing concerns about the potential for instability in the region.

Other issues such as education, space exploration, and technology collaborations may also be discussed during the visit.