What are the hidden disease risks flagged by a genetic map of Indians?

A genetic map of Indians has revealed several hidden disease risks due to unique genetic variations.

• High prevalence of rare genetic disorders: Certain rare diseases like thalassemia, sickle cell anemia, and metabolic disorders are more common due to founder effects and endogamy.
• Increased risk of diabetes and heart disease: Specific gene variants linked to type 2 diabetes and cardiovascular disease are more frequent in Indian populations.
• Susceptibility to infectious diseases: Genetic factors may influence vulnerability to diseases like tuberculosis and leprosy.
• Drug response variation: Genetic diversity affects how Indians respond to medications, impacting drug efficacy and safety.

Implications: These findings highlight the need for population-specific screening, personalized medicine, and targeted interventions to address the unique health challenges faced by Indians.