There are several factors that can increase the risk of severe disease and mortality due to COVID-19, especially for older people and those with co-morbidities. Below are some of the key factors:

• Age: Older people, in particular those over 65 years of age, are at higher risk of severe illness and death from COVID-19. As we age, our immune systems naturally weaken, making it harder to fight off infections.
• Co-morbidities: People with underlying health conditions, such as heart disease, diabetes, lung disease, and obesity, are also at higher risk of severe COVID-19 illness. These conditions can put additional strain on the body's immune system, making it more difficult to fight off the virus.
• Immune system response: Some people's immune systems overreact to the virus, which can cause inflammation and damage to vital organs like the lungs, heart, and kidneys. This can lead to severe illness and even death.
• Exposure to the virus: The more exposure someone has to the virus, the higher their risk of developing severe illness. This is why healthcare workers and others who are in close contact with COVID-19 patients are at higher risk.
• Socioeconomic factors: Access to healthcare, living and working conditions, and other social factors can also play a role in determining someone's risk of severe COVID-19 illness.

It's important for all individuals to take preventive measures such as wearing masks, washing hands frequently, and practicing social distancing to reduce the overall transmission of COVID-19 and protect vulnerable populations.